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Best Diaper Rash Creams of 2021

Find the right cream for your baby's diaper rash.

At least half of all babies get a diaper rash at some point. Rashes and infections can be incredibly painful for babies, and make diaper changes far more unpleasant than they need to be.

They are a  source of endless headaches for mothers too.

The good news? Diaper rash cream can help to heal existing rashes and prevent ones from starting.

We’ve rounded up the best diaper rash creams to help protect your little one’s tushie.

Our Top Picks

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Product Comparison Table
Product Image of the Desitin Maximum Strength Baby Diaper Rash Cream
Best Maximum Strength
Desitin Maximum Strength
  • Maximum strength
  • 12 hour relief
  • Treats and prevents
Product Image of the Organic Diaper Balm by Earth Mama | Safe Calendula Cream to Soothe and Protect...
Best for Cloth Diapering
Earth Mama Angel Baby
  • Free of allergens
  • All-natural formulation
  • Antibacterial & antifungal properties
Product Image of the Aquaphor Baby Healing Ointment - Advance Therapy for Diaper Rash, Chapped Cheeks...
Best for Diarrhea
Aquaphor Baby
  • Multiple uses
  • Provides excellent moisture barrier
  • Promotes skin healing
Product Image of the Boudreaux's Butt Paste Diaper Rash Ointment Maximum Tube Paraben Preservative...
Best for Toddlers
Boudreaux’s Butt Paste
  • Protects and treats
  • Economical
  • Developed by a pharmacist
Product Image of the Burt's Bees Baby 100% Natural Origin Diaper Rash Ointment - 3 Ounces Tube
Best for Infants
Burt’s Bees Ointment
  • 100% natural
  • Paraben-free
  • Offers barrier protection & skin conditioners
Product Image of the Babo Botanicals Natural Organic Oatmilk Calendula Diaper Rash Cream With Zinc...
Best All Natural
Babo Botanicals
  • Support fair trade
  • Organic
  • All natural ingredients
Product Image of the The Honest Company, Diaper Rash Cream, 2.5 Oz
Best Orgnaic
The Honest Company
  • Organic ingredients
  • Plant based
  • Hypoallergenic
Product Image of the WELEDA Calendula Diaper Care, 3 Count
Best for Open Sores
Weleda Diaper Cream
  • Contains zinc oxide
  • Has anti-inflammatory calendula
  • No synthetic preservatives
Product Image of the Baza Moisture Barrier Antifungal Cream 5oz
Best Antifungal
Baza Moisture Barrier
  • Gives a moisture barrier
  • Antifungal
  • Multifunctional product
Product Image of the A & D Diaper Rash Ointment 4 oz. (Pack of 2)
Best for Eczema
A&D Diaper Ointment
  • Very effective
  • Provides strong moisture barrier
  • Oil-based

Why You Need Diaper Rash Cream

Diaper rash is a skin irritation in your child’s diaper area.

Sometimes it’s simply a red, irritated patch on your baby’s bottom that causes them no apparent discomfort. Other times it can be severe, spreading to their thighs or torso and causing pain. In extreme cases, the skin can bleed or become infected.

Diaper rash cream can help to both heal your child’s bottom from an existing rash, and prevent one from starting.

The right cream acts as a protective barrier between your baby’s bottom and potential irritants. Some also have soothing ingredients to calm inflammation and heal irritation.

The Causes of Diaper Rash

There are many different causes of diaper rash:

  • Moisture: Your child’s diaper is a warm, moist place and even though diapers do their best to wick that moisture away from their skin, their bum is never 100 percent dry. There’s always moisture against your baby’s skin, causing potential irritation (1).
  • Stool: When your baby’s urine mixes with their stool, it causes a chemical reaction that creates ammonia. Ammonia is harsh on the skin and can irritate it. If you are a cloth diaper user, it is important to keep cloth diapers ammonia-free.
  • Diarrhea: There’s additional acid in your child’s diarrhea — combine that with the extra moisture and the ammonia, and you’ve got a recipe for diaper rash.
  • Foods: The introduction of new foods into your baby’s diet changes the chemical composition of their stool and can irritate their tender skin. Depending on the food it may also introduce more acid into the diet, which is also an irritant when it comes out in your baby’s diaper. It’s important to note that if your child gets a diaper rash from a type of food, it doesn’t necessarily mean they’re allergic to that food. Watch for other signs of allergy in your child and talk to your doctor if you have concerns.
  • Chemicals: Disposable diapers have chemicals, dyes, and perfumes to help trap the moisture and keep it from smelling. Even “natural” diapers have some chemicals in them. If your child is repeatedly getting diaper rashes, you may need to switch to a dye-free or natural diaper for sensitive skin, or consider switching to cloth.
  • Detergents: If you use cloth diapers, your baby may be reacting to the detergent you use to wash them. You may want to consider switching brands, changing to a detergent without dyes or perfumes, or adding an extra rinse or two to your wash routine.
  • Antibiotics: Antibiotics kill bacteria that are causing illness in your child – but they also kill the healthy bacteria in your child’s digestive system. This can cause them to get diarrhea or a yeast infection, both of which cause diaper rash.
  • Yeast: Most diaper rashes are caused by topical or chemical skin irritation and are treated with over-the-counter diaper rash creams. Yeast rashes are the result of yeast (technically a fungus, but often mistakenly referred to as a bacteria) growing in your child’s diaper area and they are particularly stubborn. Yeast loves warm, moist environments — i.e., your baby’s diaper. Yeast infections need to be treated with an antifungal product, often on prescription (2).

Pro Tip

If you use cloth diapers and your child gets a yeast rash, you’ll need to go through some extra steps to kill the yeast living in the fibers of your diapers. Your regular wash routine won’t kill them. Switch to disposable diapers temporarily while you battle your baby’s yeast rash and treat your cloth diapers to prevent a recurrence of yeast.

Types of Diaper Rash Products

There are several on the market, depending on your needs.


Creams are water-based, making them easy for the skin to absorb and easy to spread. They’re best for soothing irritated skin.


Pastes are thick products that protect your baby’s skin, and typically contain zinc oxide and skin conditioners. They can stain clothing and aren’t recommended for cloth diapers (unless you use a disposable liner) as they’re difficult to wash out of fabric.


Ointments are oil-based products. Being oily and greasy, they sit on top of your child’s skin, providing a good barrier against irritants.


While baby powder is advertised as able to absorb moisture, it’s not recommended as the fine powder becomes airborne and is easily inhaled by your little one. It’s also often made of cornstarch, which provides a food source for yeast and exacerbates any rashes or infections.

How to Choose a Diaper Rash Cream

When choosing a diaper rash cream, consider the following:

Type of Rash

If your child has an irritated bottom, choose a traditional diaper cream or ointment. If they have a yeast rash, you’ll need an antifungal cream, as regular products won’t help.

Cream, Paste, or Ointment

If you’re using a product as a preventative measure, an ointment may be your best bet. If you’re healing an existing rash, cream may soothe the skin. And if your baby has a particularly severe rash, an ultra-thick paste may both heal the skin and protect it.

Cloth or Disposable Diapers

If you use disposable diapers, you don’t have to worry about diaper creams affecting their performance. If you use cloth, however, some ingredients in creams or ointments can clog the fibers and make them less absorbent. If you use cloth, choose diaper creams without the petrolatum or zinc oxide. You may also want to use a disposable liner.


Many diaper creams and ointments contain ingredients that have the potential to be irritants. If your child has a sensitivity, check the label for potential allergens such as lanolin, mineral oil, coconut oil, beeswax, and sunflower oil.

The Best Diaper Rash Creams of 2021

Here are the top diaper rash creams on the market.

1. Desitin Maximum Strength Baby Diaper Rash Cream

Best Maximum-Strength Diaper Rash Cream

This hypoallergenic formula is paraben, phthalate, dye, and soap-free. Dermatologically and pediatrician tested, it’s a gentle option for daily use.

However, it still uses maximum strength to effectively treat diaper rash. It’s made with 40% zinc oxide to treat and even prevent diaper rash discomfort.

This is a fantastic option for overnight use as it can provide relief for up to 12 hours. So if your little one is waking up in pain during the night, we recommend trying this.


  • Hypoallergenic.
  • Maximum strength.
  • 12-hour relief.
  • Treats and prevents.


  • Very thick so it’s hard to spread.
  • Strong bad smell.

2. Earth Mama Organic Diaper Balm

Best Diaper Rash Cream for Cloth Diapers

Finding a diaper cream with neither zinc oxide or petrolatum is near impossible, but this one fits the bill. Made of completely natural ingredients that should rinse out of your diaper completely, it offers your baby’s skin wetness protection while still allowing it to breathe.

It also contains antibacterial and antifungal herbs, which means it may help prevent and treat yeast rashes should they occur. It’s been clinically tested and dermatologist approved, and is free of some of the most common allergens including lanolin, mineral oil, beeswax, and petroleum.


  • Free of many allergens.
  • All-natural formulation is also great for sensitive skins.
  • It can safely be used on cloth diapers.
  • It has antibacterial and antifungal properties.


  • A little on the expensive side.
  • Some reviewers found the smell to be too strong.

3. Aquaphor Baby Healing Ointment for Diaper Rash

Best Diaper Rash Cream for Diarrhea

This thick, greasy ointment is easy (and painless) to apply and wipe off, and will provide a solid moisture barrier between your baby’s skin and the contents of their diaper.

Aquaphor ointment also contains panthenol and glycerin which help to moisturize and nourish the skin, promoting healing if their bum is irritated.

Aquaphor is widely recommended by dermatologists for help with a wide variety of skin issues, but this line was specifically formulated with babies’ unique skin needs in mind.

Parents find it to be very effective in treating and preventing diaper rash, but it can also be used for other skin issues such as eczema, chapped skin, and protecting cuts and scrapes.


  • It has multiple uses.
  • Provides an excellent moisture barrier.
  • Helps promote skin healing.


  • It contains petrolatum.
  • It contains potential allergens.
  • Some parents may find it feels too greasy.

4. Boudreaux's Butt Paste Diaper Rash Ointment

Best Diaper Cream for Toddlers

Developed by a father who happened to be a pharmacist, this simple paste treats your baby’s diaper rash with only six ingredients, so you know they’re not being exposed to strange chemicals.

It’s comprised primarily of zinc oxide, leaving a thick barrier between your baby’s bottom and potential irritants. The additional ingredients help to soothe baby’s skin without any strong or medicinal scents. Finally, not only will it prevent against further irritation, but it helps heal existing ones.


  • Protects and treats.
  • It’s thick for maximum coverage; this also makes it economical since you don’t need much.
  • It was developed by a pharmacist.


  • Contains petrolatum.
  • It isn’t appropriate for cloth diapers.

5. Burt’s Bees Baby Diaper Rash Ointment

Best Diaper Cream for Infants

Burt’s Bees has a great reputation for high-quality and gentle products, and their diaper rash ointment is no different. It’s safe for use on your baby’s bum with 100 percent natural ingredients and no parabens, phthalates, or petrolatum.

Made of 40 percent zinc oxide, it locks out any moisture that could irritate your baby’s skin, but also has natural conditioners to nourish at the same time. It’s been tested by pediatricians so you can be assured it’s gentle on your baby, and also has a pleasant scent that won’t make you think of medicine.


  • 100 percent natural.
  • It’s paraben-free.
  • It offers barrier protection and skin conditioners.


  • Contains beeswax and lanolin, which are allergens for some babies.
  • Not very thick.

6. Babo Botanicals Natural Diaper Rash Cream

Best Natural Diaper Rash Cream

This cream is made entirely of natural products — there’s absolutely nothing synthetic here — and it was developed on a certified organic farm so you can be sure that what goes onto your baby’s skin is as safe as possible.

It has zinc oxide as a moisture barrier, but also contains anti-inflammatory extracts to help soothe your baby’s bottom. And since it’s manufactured in small batches, they keep the quality high as opposed to mass-manufacturing where quality can be diminished.


  • They support fair trade.
  • Organic.
  • Quality, all-natural ingredients.


  • It’s expensive.
  • Some of the ingredients are potential allergens.

7. The Honest Company Diaper Rash Cream

Best Organic Diaper Rash Cream

This plant-based diaper cream is made with organic ingredients, so you know it’s as natural as possible. The zinc oxide not only forms a barrier to protect your baby’s bottom but also works to reduce inflammation on the skin that’s already irritated.

It’s certified by the NSF — which means it meets strict health and safety standards — and has been tested by physicians. It’s kind to your baby’s skin, fragrance-free, and is made without parabens, mineral oil, lanolin, or dyes.


  • Made with organic ingredients.
  • Plant based.
  • It doesn’t contain the most common allergens.
  • Hypoallergenic.


  • The coconut oil may irritate some babies.
  • Some reviewers claimed the product separated.

8. Weleda Diaper Cream with Calendula

Best Diaper Rash Cream for Open Sores

Weleda developed this cream with the help of midwives, so you know that they care about making products that actually work. As a bonus, this is certified “natural” by the European organization NaTrue.

The cream is 12% zinc oxide to offer protection, with calendula extract and other natural ingredients to soothe your baby’s extra-irritated bottom.

It contains no synthetic preservatives or fragrances and replaces traditional mineral oil with beeswax. There are also several other ingredients to further nourish your baby’s soft skin as it heals.


  • Natural product.
  • It contains zinc oxide.
  • Has anti-inflammatory calendula.
  • No synthetic preservatives.
  • Fragrance-free.


  • It contains beeswax and lanolin (potential allergens).
  • High number of ingredients.

9. Baza Moisture Barrier Antifungal Cream

Best Antifungal Diaper Rash Cream

Though this cream wasn’t developed specifically for babies, many parents have used it instead of diaper cream for their children who are battling yeast.

It contains petrolatum, which will form a barrier between your baby’s skin and diaper wetness, and also an antifungal ingredient which will help to eliminate their yeast growth.

Because diaper creams don’t come formulated with an antifungal, you will need to check with your doctor before using this product on your baby — just to make sure they give you the go-ahead. But once they do, this is nice to have in your medicine cabinet because you can use the diaper cream to heal fungal infections in the whole family.


  • It provides a moisture barrier.
  • It has an antifungal to help with yeast.
  • Multifunctional product.


  • Not specifically approved for babies.
  • It contains synthetic products.

10. A&D Diaper Rash Ointment

Best Diaper Cream for Eczema

Nothing offers barrier protection quite like oil-based ointments, and at 53 percent petrolatum, this will keep all irritants off your baby’s already-irritated skin. It also contains lanolin, which is designed to help treat and heal your baby’s diaper rash.

Because it’s oil-based, it’s easy to apply to your baby’s skin and won’t cause them discomfort as you try to spread it across their sore diaper area. The same is true when you clean it later — because it’s not a thick paste, it wipes off easily, so you don’t have to scrub your baby’s poor tushie.


  • Very effective.
  • It provides a strong moisture barrier.


  • Contains a fragrance.
  • Contains potential allergens.
  • Petrolatum is a synthetic product.


The Bottom Line

Our top pick for the best diaper cream is the Desitin Maximum Strength Baby Diaper Rash Cream. Not only is hypoallergenic, maximum strength, and free from nearly all the major potential allergens, but it can be used on whatever type of diaper you choose and even has antifungal properties that may help you battle, or prevent yeast.

It can be tricky to find the right diaper cream for your little one, so when you finally find one that works, you’ll be loyal to it for the whole of your parenting career.

Headshot of Mary Sweeney, BSN, RN, CEN

Reviewed by

Mary Sweeney, BSN, RN, CEN

Mary Sweeney, BSN, RN, CEN is an oncology nurse navigator and freelance medical writer. Mary has 4 years of experience as an officer in the Navy Nurse Corps. including emergency/trauma, post-anesthesia, and deployment medicine.